Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer’s Disease
HMGB1 is a prototypical danger-associated molecular pattern (DAMP) molecule that co-localizes with amyloid beta (Aβ) in the brains of patients with Alzheimer’s disease. HMGB1 levels are significantly higher in the cerebrospinal fluid of patients. However, the cellular and subcellular distribution of...
Main Authors: | Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Lee |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-01-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/13/2/189 |
Similar Items
-
Cytosolic HMGB1 Mediates LPS-Induced Autophagy in Microglia by Interacting with NOD2 and Suppresses Its Proinflammatory Function
by: Seung-Woo Kim, et al.
Published: (2022-08-01) -
HMGB1 INDUCES HEPCIDIN UPREGULATION IN ASTROCYTES OF THE ISCHEMIC BRAIN AND CAUSES AN ACUTE IRON SURGE AND SUBSEQUENT FERROPTOSIS
by: Ja-Kyeong Lee, et al.
Published: (2023-10-01) -
Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review
by: Seung-Woo Kim, et al.
Published: (2020-07-01) -
Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer’s Disease
by: Sedra Alabed, et al.
Published: (2021-04-01) -
HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain
by: Dashdulam Davaanyam, et al.
Published: (2023-11-01)