Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases

Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases

Abstract Tumor metastasis accounts for the majority of cancer-related deaths; it is therefore important to develop preclinical models that faithfully recapitulate disease progression. Here, we generated paired organoids derived from primary tumors and matched liver metastases in the same colorectal...

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Bibliographic Details
Main Authors: He Li, Weixing Dai, Xi Xia, Renjie Wang, Jing Zhao, Lingyu Han, Shaobo Mo, Wenqiang Xiang, Lin Du, Guangya Zhu, Jingjing Xie, Jun Yu, Nan Liu, Mingzhu Huang, Jidong Zhu, Guoxiang Cai
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Hematology & Oncology
Subjects:
Colorectal cancer
Tumor metastasis
Preclinical model
Paired organoids
SOX2
Online Access:http://link.springer.com/article/10.1186/s13045-020-00957-4

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http://link.springer.com/article/10.1186/s13045-020-00957-4

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