Re-Engineering Therapeutic Anti-Aβ Monoclonal Antibody to Target Amyloid Light Chain

Re-Engineering Therapeutic Anti-Aβ Monoclonal Antibody to Target Amyloid Light Chain

Amyloidosis involves the deposition of misfolded proteins. Even though it is caused by different pathogenic mechanisms, in aggregate, it shares similar features. Here, we tested and confirmed a hypothesis that an amyloid antibody can be engineered by a few mutations to target a different species. Am...

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Bibliographic Details
Main Authors: Jingyi Bai, Xi Li, Jun Zhao, Huifang Zong, Yuan Yuan, Lei Wang, Xiaoshuai Zhang, Yong Ke, Lei Han, Jianrong Xu, Buyong Ma, Baohong Zhang, Jianwei Zhu
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
β-amyloid
amyloid light chain
amyloidosis
mAb
antibody design
Online Access:https://www.mdpi.com/1422-0067/25/3/1593

Internet

https://www.mdpi.com/1422-0067/25/3/1593

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