Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells

Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells

The mouse <i>mahoganoid</i> mutation abrogating Mahogunin Ring Finger-1 (MGRN1) E3 ubiquitin ligase expression causes hyperpigmentation, congenital heart defects and neurodegeneration. To study the pathophysiology of MGRN1 loss, we compared <i>Mgrn1</i>-knockout melanocytes w...

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Bibliographic Details
Main Authors: Idoya Martínez-Vicente, Marta Abrisqueta, Cecilia Herraiz, Julia Sirés-Campos, María Castejón-Griñán, Dorothy C. Bennett, Conchi Olivares, Jose Carlos García-Borrón, Celia Jiménez-Cervantes
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
Mahogunin Ring Finger 1
melanoma
melanocytes
genomic stability
DNA damage
cell cycle
Online Access:https://www.mdpi.com/2072-6694/12/10/2840

Internet

https://www.mdpi.com/2072-6694/12/10/2840

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