Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

Fanconi anemia is a complex disease affecting multiple DNA repair proteins that resolve DNA crosslinks which can block vital processes. Here the authors use parallel genome-wide screens that identify the BLM helicase complex as a suppressor of Fanconi anemia phenotypes.

Bibliographic Details
Main Authors: Martin Moder, Georgia Velimezi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Joana Ferreira da Silva, Lydia Robinson-Garcia, Fiorella Schischlik, Rastislav Slavkovsky, Robert Kralovics, Michael Schuster, Christoph Bock, Trey Ideker, Stephen P. Jackson, Jörg Menche, Joanna I. Loizou
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01439-x

Internet

https://doi.org/10.1038/s41467-017-01439-x

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