Anti-EGFR Targeted Multifunctional I-131 Radio-Nanotherapeutic for Treating Osteosarcoma: In Vitro 3D Tumor Spheroid Model

Anti-EGFR Targeted Multifunctional I-131 Radio-Nanotherapeutic for Treating Osteosarcoma: In Vitro 3D Tumor Spheroid Model

The systemic delivery of doxorubicin (DOX) to treat osteosarcoma requires an adequate drug concentration to be effective, but in doing so, it raises the risk of increasing organ off-target toxicity and developing drug resistance. Herein, this study reveals a multiple therapeutic nanocarrier delivery...

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Bibliographic Details
Main Authors: Suphalak Khamruang Marshall, Boonyisa Saelim, Maneerat Taweesap, Verachai Pachana, Yada Panrak, Naritsara Makchuchit, Passara Jaroenpakdee
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Nanomaterials
Subjects:
3D spheroid
cancer treatment
doxorubicin
EGFR targeted therapy
epidermal growth factor receptor
I-131
Online Access:https://www.mdpi.com/2079-4991/12/19/3517

Internet

https://www.mdpi.com/2079-4991/12/19/3517

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