High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes

High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes

The DNA Damage Response (DDR) pathways sense DNA damage and coordinate robust DNA repair and bypass mechanisms. A series of repair proteins are recruited depending on the type of breaks and lesions to ensure overall survival. An increase in glucose levels was shown to induce genome instability, yet...

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Bibliographic Details
Main Authors: Mai A. Rahmoon, Reem A. Elghaish, Aya A. Ibrahim, Zina Alaswad, Mohamed Z. Gad, Sherif F. El-Khamisy, Menattallah Elserafy
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Genes
Subjects:
DNA damage response (DDR)
hyperglycemia (HG)
DNA damage
metabolic diseases
cancer
diabetes mellitus
Online Access:https://www.mdpi.com/2073-4425/14/1/144

Internet

https://www.mdpi.com/2073-4425/14/1/144

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