Evaluation of New Antimicrobial Agents Based on <i>tris</i>(1<i>H</i>-Indol-3-yl)methylium Salts: Activity, Toxicity, Suppression of Experimental Sepsis in Mice

Evaluation of New Antimicrobial Agents Based on <i>tris</i>(1<i>H</i>-Indol-3-yl)methylium Salts: Activity, Toxicity, Suppression of Experimental Sepsis in Mice

The antimicrobial activity and toxicity of three novel synthetic antibacterial agents containing <i>tris</i>(1<i>H</i>-indol-3-yl)methylium fragment were studied in vitro and in vivo. All compounds in vitro revealed high activity (minimal inhibitory concentration (MIC) 0.13–1...

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Bibliographic Details
Main Authors: Alexey S. Trenin, Elena B. Isakova, Michael I. Treshchalin, Vasilisa A. Polozkova, Elena P. Mirchink, Alexey A. Panov, Alexander Y. Simonov, Olga P. Bychkova, Victor V. Tatarskiy, Sergey N. Lavrenov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
<i>tris</i>(1<i>H</i>-indol-3-yl)methylium
turbomycin
overcoming of drug resistance
toxicity in vitro and in vivo
staphylococcal sepsis
Online Access:https://www.mdpi.com/1424-8247/15/2/118

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https://www.mdpi.com/1424-8247/15/2/118

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