Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials. In order for PFS to be accepted as a patient-relevant outcome within the benefit assessment of pharmaceuticals in accordance with the German Social Cod...

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Bibliographic Details
Main Authors: Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm
Format: Article
Language:deu
Published: German Medical Science GMS Publishing House 2017-01-01
Series:GMS Medizinische Informatik, Biometrie und Epidemiologie
Subjects:
validation of surrogates
correlation
surrogate threshold effect
progression-free survival
benefit assessment
Online Access:http://www.egms.de/static/en/journals/mibe/2017-13/mibe000168.shtml

Internet

http://www.egms.de/static/en/journals/mibe/2017-13/mibe000168.shtml

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