Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction

Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction

Myocardial contractile dysfunction in diabetic cardiomyocytes is a significant promoter of heart failure. Herein, we investigated the effect of icariin, a flavonoid monomer isolated from Epimedium, on diabetic cardiomyopathy (DCM) and explored the mechanisms underlying its unique pharmacological car...

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Bibliographic Details
Main Authors: Tingjuan Ni, Na Lin, Xingxiao Huang, Wenqiang Lu, Zhenzhu Sun, Jie Zhang, Hui Lin, Jufang Chi, Hangyuan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
icariin
diabetic cardiomyopathy, DCM
mitochondrial dysfunction
cardiac dysfunction
Apelin/Sirt3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00256/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00256/full

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