Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets
Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought to be either destruction by autoimmune T cells or d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12974-020-01944-9 |
| _version_ | 1819062960980492288 |
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| author | Vaidya Govindarajan Juan Pablo de Rivero Vaccari Robert W. Keane |
| author_facet | Vaidya Govindarajan Juan Pablo de Rivero Vaccari Robert W. Keane |
| author_sort | Vaidya Govindarajan |
| collection | DOAJ |
| description | Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought to be either destruction by autoimmune T cells or dysfunction of myelin-producing cells. Recent advances have indicated that inflammasomes contribute the etiology of MS. Inflammasomes are multiprotein complexes of the innate immune response involved in the processing of caspase-1, the activation of pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as the cell death-mediated mechanism of pyroptosis and the activation of the adaptive immune response. Here we review the literature to date on the role of different inflammasome signaling pathways in the pathogenesis of MS and how these pathways may be targeted to reduce deleterious inflammatory processes and improve outcomes in this patient population. |
| first_indexed | 2024-12-21T15:07:05Z |
| format | Article |
| id | doaj.art-bcadab320da84bd9a9d02f80a9c24047 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-21T15:07:05Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-bcadab320da84bd9a9d02f80a9c240472022-12-21T18:59:24ZengBMCJournal of Neuroinflammation1742-20942020-09-0117111510.1186/s12974-020-01944-9Role of inflammasomes in multiple sclerosis and their potential as therapeutic targetsVaidya Govindarajan0Juan Pablo de Rivero Vaccari1Robert W. Keane2Department of Physiology and Biophysics, University of Miami Miller School of MedicineDepartment of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of MedicineDepartment of Physiology and Biophysics, University of Miami Miller School of MedicineAbstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and it remains the most common immune-mediated disorder affecting the CNS. While the cause of MS is unclear, the underlying pathomechanisms are thought to be either destruction by autoimmune T cells or dysfunction of myelin-producing cells. Recent advances have indicated that inflammasomes contribute the etiology of MS. Inflammasomes are multiprotein complexes of the innate immune response involved in the processing of caspase-1, the activation of pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as the cell death-mediated mechanism of pyroptosis and the activation of the adaptive immune response. Here we review the literature to date on the role of different inflammasome signaling pathways in the pathogenesis of MS and how these pathways may be targeted to reduce deleterious inflammatory processes and improve outcomes in this patient population.http://link.springer.com/article/10.1186/s12974-020-01944-9Inflammasomemultiple sclerosisEAEcaspase-1IL-1β |
| spellingShingle | Vaidya Govindarajan Juan Pablo de Rivero Vaccari Robert W. Keane Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets Journal of Neuroinflammation Inflammasome multiple sclerosis EAE caspase-1 IL-1β |
| title | Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets |
| title_full | Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets |
| title_fullStr | Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets |
| title_full_unstemmed | Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets |
| title_short | Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets |
| title_sort | role of inflammasomes in multiple sclerosis and their potential as therapeutic targets |
| topic | Inflammasome multiple sclerosis EAE caspase-1 IL-1β |
| url | http://link.springer.com/article/10.1186/s12974-020-01944-9 |
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