Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism

Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism

Intestine-Liver-on-chip systems can be useful to predict oral drug administration and first-pass metabolism in vitro in order to partly replace the animal model. While organ-on-chip technology can count on sophisticated micro-physiological devices, the engineered organs still remain artificial surro...

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Bibliographic Details
Main Authors: Vincenza De Gregorio, Mariarosaria Telesco, Brunella Corrado, Valerio Rosiello, Francesco Urciuolo, Paolo A. Netti, Giorgia Imparato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
first-pass metabolism of ethanol (Et-OH)
intestine-liver-on-chip
bottom-up tissue engineering approach
endogenous ECM
3D tissue
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00163/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00163/full

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