Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

<p>Abstract</p> <p>Background</p> <p>Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-in...

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Bibliographic Details
Main Authors: Impagnatiello Francesco, Serra Pier A, Testa Nunzio, Caniglia Salvatore, Tirolo Cataldo, L'Episcopo Francesca, Morale Maria C, Marchetti Bianca
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/7/1/83

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http://www.jneuroinflammation.com/content/7/1/83

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