Combining Everolimus and Ku0063794 Promotes Apoptosis of Hepatocellular Carcinoma Cells via Reduced Autophagy Resulting from Diminished Expression of miR-4790-3p

Combining Everolimus and Ku0063794 Promotes Apoptosis of Hepatocellular Carcinoma Cells via Reduced Autophagy Resulting from Diminished Expression of miR-4790-3p

It is challenging to overcome the low response rate of everolimus in the treatment of patients with hepatocellular carcinoma (HCC). To overcome this challenge, we combined everolimus with Ku0063794, the inhibitor of mTORC1 and mTORC2, to achieve higher anticancer effects. However, the precise mechan...

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Bibliographic Details
Main Authors: Ho Joong Choi, Jung Hyun Park, Ok-Hee Kim, Kee-Hwan Kim, Ha Eun Hong, Haeyeon Seo, Say-June Kim
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
hepatocellular carcinoma
miR-4790-3p
mTOR inhibitor
ZNF225
Online Access:https://www.mdpi.com/1422-0067/22/6/2859

Internet

https://www.mdpi.com/1422-0067/22/6/2859

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