A mathematical investigation of polyaneuploid cancer cell memory and cross-resistance in state-structured cancer populations

A mathematical investigation of polyaneuploid cancer cell memory and cross-resistance in state-structured cancer populations

Abstract The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-resistance to classes of therapies with independent...

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Bibliographic Details
Main Authors: Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42368-8

Internet

https://doi.org/10.1038/s41598-023-42368-8

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