Structural Basis for the Regulation of L-type Voltage-gated Calcium Channels: Interactions between the N-terminal cytoplasmic Domain and Ca2+-Calmodulin
It is well known that the opening of L-type voltage-gated calcium channels can be regulated by calmodulin. One of the main regulatory mechanisms is CDI (calcium-dependent inactivation), where binding of apo-calmodulin (CaM) to the cytoplasmic C-terminal domain of the channel can effectively sense an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00038/full |