Synthesis, biological evaluation and molecular docking studies of tetrahydropyrido[3, 4-d]pyrimidine derivatives as anti-leukemic agents

Synthesis, biological evaluation and molecular docking studies of tetrahydropyrido[3, 4-d]pyrimidine derivatives as anti-leukemic agents

Substituted tetrahydropyrido[3,4-d]pyrimidine derivatives (2a-l) have been synthesized through a series of N-substitution, Suzuki coupling, deprotection and condensation reactions. The structure of new compounds was analysed by interpretations of FTIR,1H NMR, 13C NMR, and mass spectral data. The syn...

Full description

Bibliographic Details
Main Authors: V. Parashuram, K. Aruna Kumari, Sai Charitha Mullaguri, Rama Krishna Kancha, Vasantha Mittapelli
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Results in Chemistry
Subjects:
Pyrido[3,4-d]pyrimidine
Suzuki coupling
Anti-leukaemic activity
Drug resistance
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624002509

Internet

http://www.sciencedirect.com/science/article/pii/S2211715624002509

Similar Items