Eribulin mesylate targets human telomerase reverse transcriptase in ovarian cancer cells.

Treatment of advanced ovarian cancer involves platinum-based chemotherapy. However, chemoresistance is a major obstacle. Cancer stem cells (CSCs) are thought to be one of the causes of chemoresistance, but the underlying mechanism remains elusive. Recently, human telomerase reverse transcriptase (hT...

Full description

Bibliographic Details
Main Authors: Satoko Yamaguchi, Yoshiko Maida, Mami Yasukawa, Tomoyasu Kato, Masayuki Yoshida, Kenkichi Masutomi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4223061?pdf=render