1H-NMR metabolomics investigation of CSF from children with HIV reveals altered neuroenergetics due to persistent immune activation

1H-NMR metabolomics investigation of CSF from children with HIV reveals altered neuroenergetics due to persistent immune activation

BackgroundHIV can invade the central nervous system (CNS) early during infection, invading perivascular macrophages and microglia, which, in turn, release viral particles and immune mediators that dysregulate all brain cell types. Consequently, children living with HIV often present with neurodevelo...

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Bibliographic Details
Main Authors: Anicia Thirion, Du Toit Loots, Monray E. Williams, Regan Solomons, Shayne Mason
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Neuroscience
Subjects:
pediatric
human immunodeficiency virus (HIV)
cerebrospinal fluid (CSF)
HIV-associated neurocognitive disorder (HAND)
proton nuclear magnetic resonance (1H-NMR)
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1270041/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2024.1270041/full

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