Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening

Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening

Leukemias are neoplasms that affect hematopoietic cells, which are developed by genetic alterations (mutations) that lead to the loss of proliferation control mechanisms (maturation and/or cell death). The α4β1 integrin receptor is a therapeutic target for inflammation, autoimmune...

Full description

Bibliographic Details
Main Authors: Elenilze F. B. Ferreira, Luciane B. Silva, Glauber V. Costa, Josivan S. Costa, Mayara A. T. Fujishima, Rozires P. Leão, André L. S. Ferreira, Leonardo B. Federico, Carlos H. T. P. Silva, Joaquín M. C. Rosa, Williams J. C. Macêdo, Cleydson B. R. Santos
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
leukemia
α4β1 receptor
pharmacophore
PCA
HCA
Online Access:https://www.mdpi.com/1420-3049/24/16/2943

Internet

https://www.mdpi.com/1420-3049/24/16/2943

Similar Items