Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways

Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways

Abstract Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, and have achieved remarkable success in the treatment of patients with refractory leukemia and lymphoma. However, dysfunction of T cells, including exhaustion, is an inevitable obstacle for per...

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Bibliographic Details
Main Authors: Mi Shao, Xinyi Teng, Xin Guo, Hao Zhang, Yue Huang, Jiazhen Cui, Xiaohui Si, Lijuan Ding, Xiujian Wang, Xia Li, Jimin Shi, Mingming Zhang, Delin Kong, Tianning Gu, Yongxian Hu, Pengxu Qian, He Huang
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Advanced Science
Subjects:
calcium signaling
chimeric antigen receptor T
exhaustion
glycolysis
store‐operated calcium entry
Online Access:https://doi.org/10.1002/advs.202103508

Internet

https://doi.org/10.1002/advs.202103508

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