Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

This study identifies the evolutionarily conserved Exportin 4 as an essential regulator in the nuclear export of circRNAs. Defective circRNA export results in R-loop formation and DNA damage in cells, as well as testis and neurological defects in mice.

Bibliographic Details
Main Authors: Liang Chen, Yucong Wang, Jiamei Lin, Zhenxing Song, Qinwei Wang, Wenfang Zhao, Yan Wang, Xiaoyu Xiu, Yuqi Deng, Xiuzhi Li, Qiqi Li, Xiaolin Wang, Jingxin Li, Xu Liu, Kunpeng Liu, Jincong Zhou, Kuan Li, Yuchan Liu, Shanhui Liao, Qin Deng, Chao Xu, Qianwen Sun, Shengzhou Wu, Kaiming Zhang, Min-Xin Guan, Tianhua Zhou, Fei Sun, Xiujun Cai, Chuan Huang, Ge Shan
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33356-z

Internet

https://doi.org/10.1038/s41467-022-33356-z

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