Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions
Abstract Background Coessentiality networks derived from CRISPR screens in cell lines provide a powerful framework for identifying functional modules in the cell and for inferring the roles of uncharacterized genes. However, these networks integrate signal across all underlying data and can mask str...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-022-02712-z |