Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration

Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors. The pathological changes associated with IVDD include the excessive accumulation of reactive oxygen species (ROS), cellular pyroptosis, and extracellular matrix (ECM) degradation. There are currently no appr...

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Bibliographic Details
Main Authors: Hao Zhou, Jinpeng He, Renfeng Liu, Jun Cheng, Yuhao Yuan, Wanpu Mao, Jun Zhou, Honghui He, Qianqi Liu, Wei Tan, Cijun Shuai, Youwen Deng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-07-01
Series:Bioactive Materials
Subjects:
Intervertebral disc degeneration
Metal-phenolic network
Pyroptosis
IL-17/ERK signaling pathway
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000811

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X24000811

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