sTREM2 mediates the associations of minimal depressive symptoms with amyloid pathology in prodromal Alzheimer’s disease: The CABLE study

Abstract The effects of microglial activation on the associations between depression and Alzheimer’s disease (AD) are still unclear. TREM2 gene plays a pivotal role in microglial activation, has been identified as a risk factor for AD. In this work, we aimed to assess the interrelationships of solub...

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Bibliographic Details
Main Authors: Zhi-Bo Wang, Yan Sun, Ya-Hui Ma, Yan Fu, Hao Hu, Wei Xu, Zuo-Teng Wang, Ling-Zhi Ma, Lan Tan, Jin-Tai Yu
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-01910-4