Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling

Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling

Osteoarthritis (OA), in which M1 macrophage polarization in the synovium exacerbates disease progression, is a major cause of cartilage degeneration and functional disabilities. Therapeutic strategies of OA designed to interfere with the polarization of macrophages have rarely been reported. Here, w...

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Bibliographic Details
Main Authors: Ziying Sun, Qianqian Liu, Zhongyang Lv, Jiawei Li, Xingquan Xu, Heng Sun, Maochun Wang, Kuoyang Sun, Tianshu Shi, Zizheng Liu, Guihua Tan, Wenqiang Yan, Rui Wu, Yannick Xiaofan Yang, Shiro Ikegawa, Qing Jiang, Yang Sun, Dongquan Shi
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SHP2
SHP099
Osteoarthritis
Synovitis
Toll-like receptor signaling
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000600

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http://www.sciencedirect.com/science/article/pii/S2211383522000600

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