AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats

AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats

Abstract Background Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. The use of adeno-associated virus (AAV) vectors for gene therapy in human clinical trials has shown promise, as AAV generally causes a very mild immune response and long-term gene transfer, and there...

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Bibliographic Details
Main Authors: Hung-Chen Wang, Kuang-I Cheng, Kuang-Yi Tseng, Aij-Lie Kwan, Lin-Li Chang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Medicine
Subjects:
Adeno-associated virus
Extracellular signal-regulated kinase (ERK) phosphorylation
Glycine receptors
Prostaglandin E2
Inflammatory pain
Online Access:https://doi.org/10.1186/s10020-023-00606-9

Internet

https://doi.org/10.1186/s10020-023-00606-9

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