α-Acylamino-β-lactone <i>N</i>-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and Protection of Human Cells from Hydrogen Peroxide-Induced Oxidative Stress

α-Acylamino-β-lactone <i>N</i>-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and Protection of Human Cells from Hydrogen Peroxide-Induced Oxidative Stress

<i>N</i>-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that preferentially catalyzes the hydrolysis of endogenous lipid mediators such as palmitoylethanolamide, which has been shown to exhibit neuroprotective and antinociceptive properties by engaging peroxisom...

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Bibliographic Details
Main Authors: Agnese Gagliardi, Roberto Molinaro, Massimo Fresta, Andrea Duranti, Donato Cosco
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antioxidants
Subjects:
PLGA nanoparticles
photostability
antioxidant activity
<i>N</i>-acylethanolamine-hydrolyzing acid amidase (NAAA)
NAAA inhibitors
URB866
Online Access:https://www.mdpi.com/2076-3921/11/4/686

Internet

https://www.mdpi.com/2076-3921/11/4/686

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