α-Acylamino-β-lactone <i>N</i>-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and Protection of Human Cells from Hydrogen Peroxide-Induced Oxidative Stress
<i>N</i>-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that preferentially catalyzes the hydrolysis of endogenous lipid mediators such as palmitoylethanolamide, which has been shown to exhibit neuroprotective and antinociceptive properties by engaging peroxisom...
Main Authors: | Agnese Gagliardi, Roberto Molinaro, Massimo Fresta, Andrea Duranti, Donato Cosco |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-03-01
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Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/11/4/686 |
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