Exosomal miR-223-3p from bone marrow mesenchymal stem cells targets HDAC2 to downregulate STAT3 phosphorylation to alleviate HBx-induced ferroptosis in podocytes

Exosomal miR-223-3p from bone marrow mesenchymal stem cells targets HDAC2 to downregulate STAT3 phosphorylation to alleviate HBx-induced ferroptosis in podocytes

Background: Hepatitis B virus associated-glomerulonephritis (HBV-GN) is one of the major secondary renal diseases in China, and microRNAs (miRNAs) in bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exo) can attenuate HBV-X protein (HBx)-induced ferroptosis in renal podocytes, but the exact...

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Bibliographic Details
Main Authors: Yueqi Chen, Xiaoqian Yang, Moxuan Feng, Yani Yu, Yongzheng Hu, Wei Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
hepatitis B virus associated glomerulonephritis
bone marrow mesenchymal stem cells
exosome
MiR-223-3p
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1327149/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1327149/full

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