Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum

Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum

Abstract Background l-Histidine biosynthesis is embedded in an intertwined metabolic network which renders microbial overproduction of this amino acid challenging. This is reflected in the few available examples of histidine producers in literature. Since knowledge about the metabolic interplay is l...

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Bibliographic Details
Main Authors: Andreas Schwentner, André Feith, Eugenia Münch, Judith Stiefelmaier, Ira Lauer, Lorenzo Favilli, Christoph Massner, Johannes Öhrlein, Bastian Grund, Andrea Hüser, Ralf Takors, Bastian Blombach
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Biotechnology for Biofuels
Subjects:
Modularized metabolic engineering
LC/MS-QToF-based systems metabolic profiling (SMP)
Flux balance analysis (FBA)
Energy engineering
l-Histidine production
Corynebacterium glutamicum
Online Access:http://link.springer.com/article/10.1186/s13068-019-1410-2

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http://link.springer.com/article/10.1186/s13068-019-1410-2

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