Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer

Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer

Summary: Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression, albeit with often uncharacterized roles in altering cell signaling states. Here, we integrate genomic and proteomic data for 5,598 tumor samples to identify CNVs leading to aberrant signal tr...

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Bibliographic Details
Main Authors: Danish Memon, Michael B. Gill, Evangelia K. Papachristou, David Ochoa, Clive S. D’Santos, Martin L. Miller, Pedro Beltrao
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
cancer
copy number aberrations
genetic associations
phospho-regulation
kinase addiction
precision medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004976

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http://www.sciencedirect.com/science/article/pii/S2211124721004976

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