Preclinical safety and efficacy of 24R,25-dihydroxyvitamin D3 or lactosylceramide treatment to enhance fracture repair

Preclinical safety and efficacy of 24R,25-dihydroxyvitamin D3 or lactosylceramide treatment to enhance fracture repair

Background/Objective: Cyp24a1-null mice deficient in 24,25(OH)2D3 display impaired callus formation during the endochondral phase of bone fracture repair. The 24,25(OH)2D3 metabolite acted by binding to the TLC domain containing 3B isoform 2 (TLCD3B2, previously named FAM57B2) effector protein, whic...

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Bibliographic Details
Main Authors: Corine Martineau, Martin Kaufmann, Alice Arabian, Glenville Jones, René St-Arnaud
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Orthopaedic Translation
Subjects:
24,25-dihydroxyvitamin D
Bone
Family with sequence similarity 57B, isoform 2 (FAM57B2)
Fracture
Lactosylceramide
Repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X20300437

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http://www.sciencedirect.com/science/article/pii/S2214031X20300437

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