5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients

5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients

Although the cytotoxic chemotherapeutic agent 5-fluorouracil (5-FU) is generally considered to directly kill cancer cells and exert immunostimulatory effects in advanced gastric cancer, accumulating evidence indicates that it upregulates the expression of PD-L1, a representative immune checkpoint bl...

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Bibliographic Details
Main Authors: Min Zhang, Yibo Fan, Xiaofang Che, Kezuo Hou, Chaoxu Zhang, Ce Li, Ti Wen, Shuo Wang, Yu Cheng, Yunpeng Liu, Xiujuan Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
exosomal PD-L1
5-fluorouracil
gastric cancer
immunosuppression
nivolumab
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00492/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00492/full

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