PCSK9 is minimally associated with HDL but impairs the anti-atherosclerotic HDL effects on endothelial cell activation

PCSK9 is minimally associated with HDL but impairs the anti-atherosclerotic HDL effects on endothelial cell activation

Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) regulates the cell-surface localization of LDL receptors in hepatocytes and is associated with LDL and lipoprotein(a) [Lp(a)] uptake, reducing blood concentrations. However, the connection between PCSK9 and HDL is unclear. Here, we investigated t...

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Bibliographic Details
Main Authors: Ioannis Dafnis, Aikaterini N. Tsouka, Christina Gkolfinopoulou, Constantinos C. Tellis, Angeliki Chroni, Alexandros D. Tselepis
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Lipid Research
Subjects:
ApoA-I
Atheroprotection
Cardiovascular disease
LDL
Lp(a)
plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001055

Internet

http://www.sciencedirect.com/science/article/pii/S0022227522001055

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