Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics

Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics

The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the cellular receptor Niemann-Pick C1 protein (NPC1) are essential step...

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Bibliographic Details
Main Authors: Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, James B. Munro
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
ebola virus
envelope glycoprotein
conformational dynamics
single-molecule fret
virus entry
Online Access:https://www.mdpi.com/1999-4915/12/1/103

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https://www.mdpi.com/1999-4915/12/1/103

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