LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling

LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling

The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3) expression and signaling, and examine underlying mecha...

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Bibliographic Details
Main Authors: Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
host defense peptide
innate immunity
NF-κB
poly I:C
toll-like receptor 3
Online Access:https://www.mdpi.com/2227-9059/10/2/492

Internet

https://www.mdpi.com/2227-9059/10/2/492

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