Interleukin-9 production by type 2 innate lymphoid cells induces Paneth cell metaplasia and small intestinal remodeling

Interleukin-9 production by type 2 innate lymphoid cells induces Paneth cell metaplasia and small intestinal remodeling

Abstract Paneth cell metaplasia (PCM) typically arises in pre-existing gastrointestinal (GI) diseases; however, the mechanistic pathway that induces metaplasia and whether PCM is initiated exclusively by disorders intrinsic to the GI tract is not well known. Here, we describe the development of PCM...

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Bibliographic Details
Main Authors: Chengyin Yuan, Aditya Rayasam, Alison Moe, Michael Hayward, Clive Wells, Aniko Szabo, Andrew Mackenzie, Nita Salzman, William R. Drobyski
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43248-5

Internet

https://doi.org/10.1038/s41467-023-43248-5

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