Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease

Abstract Background To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ) and tau burden and their longitudinal changes in Alzheimer’s disease (AD) spectrum. Methods Among 272 individuals who underwent PET scans (18F-florbetaben for Aβ and 18F-flortaucipir for tau) and ApoE...

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Bibliographic Details
Main Authors: Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer disease
Amyloid-β
ApoE
Positron emission tomography
Tau
Online Access:http://link.springer.com/article/10.1186/s13195-020-00710-6

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http://link.springer.com/article/10.1186/s13195-020-00710-6

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