Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi

S. aureus infection of bone is difficult to eradicate due to its ability to colonize the osteocyte-lacuno-canalicular network (OLCN), rendering it resistant to standard-of-care (SOC) antibiotics. To overcome this, we proposed two bone-targeted bisphosphonate-conjugated antibiotics (BCA): bisphosphon...

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Bibliographic Details
Main Authors: Youliang Ren, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Chad A. Galloway, Yuting Liu, Philip Cherian, Jeffrey Neighbors, Marloes I. Hofstee, Frank H. Ebetino, Thomas Fintan Moriarty, Shuting Sun, Edward M. Schwarz, Chao Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
osteomyelitis
Staphylococcus aureus
transmission electron microscopy
antibiotic
bisphosphonate
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.910970/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.910970/full

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