Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone

Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone

BackgroundCombination antiretroviral therapy (ART) use in pregnancy has been pivotal in improving maternal health and reducing perinatal HIV transmission. However, children born HIV-exposed uninfected fall behind their unexposed peers in several areas including neurodevelopment. The contribution of...

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Bibliographic Details
Main Authors: Shreya H. Dhume, Kayode Balogun, Ambalika Sarkar, Sebastian Acosta, Howard T. J. Mount, Lindsay S. Cahill, John G. Sled, Lena Serghides
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
HIV antiretrovirals
protease inhibitors
neurodevelopment
cognition
HEU
hyperactivity
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1376681/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1376681/full

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