Chronic Disruption of the Late Cholesterol Synthesis Leads to Female-Prevalent Liver Cancer

Chronic Disruption of the Late Cholesterol Synthesis Leads to Female-Prevalent Liver Cancer

While the role of cholesterol in liver carcinogenesis remains controversial, hepatocellular carcinoma generally prevails in males. Herein, we uncover pathways of female-prevalent progression to hepatocellular carcinoma due to chronic repression of cholesterogenic lanosterol 14α-demethylase (CYP51) i...

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Bibliographic Details
Main Authors: Kaja Blagotinšek Cokan, Žiga Urlep, Gregor Lorbek, Madlen Matz-Soja, Cene Skubic, Martina Perše, Jera Jeruc, Peter Juvan, Tadeja Režen, Damjana Rozman
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
cholesterol biosynthesis
hepatocellular carcinoma
lanosterol 14α-demethylase (CYP51)
sex dimorphism
Online Access:https://www.mdpi.com/2072-6694/12/11/3302

Internet

https://www.mdpi.com/2072-6694/12/11/3302

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