Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues

Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues

Immunoglobulin M (IgM) is the largest antibody isotype with unique features like extensive glycosylation and oligomerization. Major hurdles in characterizing its properties are difficulties in the production of well-defined multimers. Here we report the expression of two SARS-CoV-2 neutralizing mono...

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Bibliographic Details
Main Authors: Somanath Kallolimath, Roman Palt, Esther Föderl-Höbenreich, Lin Sun, Qiang Chen, Florian Pruckner, Lukas Eidenberger, Richard Strasser, Kurt Zatloukal, Herta Steinkellner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
pentameric IgM
plant expression
glycosylation
monoclonal antibodies
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147960/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147960/full

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