ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis

Mammalian cells synthesize various sterol molecules, including the C30 sterol, lanosterol, as cholesterol precursors in the endoplasmic reticulum. The build-up of precursor sterols, including lanosterol, displays cellular toxicity. Precursor sterols are found in plasma HDL. How these structurally di...

Full description

Bibliographic Details
Main Authors: Yoshio Yamauchi, Shinji Yokoyama, Ta-Yuan Chang
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
acyl-CoA:cholesterol acyltransferase
cholesterol/efflux
cholesterol/trafficking
high density lipoprotein
lipid rafts
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314036

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520314036

Similar Items