A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes

A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes

Insulin plays important roles in apoptosis and lipid droplet (LD) formation, and it is one of the determinants involved in increasing fat mass. However, the mechanisms underlying insulin-induced enlargement of fat mass remain unclear. Our previous study suggested that insulin-induced increases in LD...

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Bibliographic Details
Main Authors: Minoru Ito, Michiaki Nagasawa, Naoki Omae, Masaki Tsunoda, Junichi Ishiyama, Tomohiro Ide, Yunike Akasaka, Koji Murakami
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Journal of Lipid Research
Subjects:
c-Jun N-terminal kinase 2
cell death-inducing DNA fragmentation factor-α-like effector
microarray
sterol regulatory element-binding protein-1c
de novo lipogenesis
small interfering RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520357096

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http://www.sciencedirect.com/science/article/pii/S0022227520357096

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