Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection

ABSTRACT Dengue is caused by infection with any one of four dengue viruses (DENV); the risk of severe disease appears to be enhanced by the cross-reactive or subneutralizing levels of antibody from a prior DENV infection. These antibodies opsonize DENV entry through the activating Fc gamma receptors...

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Main Authors: Candice Y. Y. Chan, John Zhong Heng Low, Esther Shuyi Gan, Eugenia Ziying Ong, Summer Li-Xin Zhang, Hwee Cheng Tan, Xiaoran Chai, Sujoy Ghosh, Eng Eong Ooi, Kuan Rong Chan
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mSphere
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00528-19