Redesigning regulatory components of quorum-sensing system for diverse metabolic control
Existing quorum sensing (QS) circuits are less sophisticated for regulating multiple sets of genes or operons. Here, the authors redesign the luxR-luxI intergenic sequence of the lux-type QS system and apply it to achieve diverse metabolic control in salicylic acid and 4-hydroxycoumarin biosynthesis...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29933-x |
| _version_ | 1818060861549314048 |
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| author | Chang Ge Zheng Yu Huakang Sheng Xiaolin Shen Xinxiao Sun Yifei Zhang Yajun Yan Jia Wang Qipeng Yuan |
| author_facet | Chang Ge Zheng Yu Huakang Sheng Xiaolin Shen Xinxiao Sun Yifei Zhang Yajun Yan Jia Wang Qipeng Yuan |
| author_sort | Chang Ge |
| collection | DOAJ |
| description | Existing quorum sensing (QS) circuits are less sophisticated for regulating multiple sets of genes or operons. Here, the authors redesign the luxR-luxI intergenic sequence of the lux-type QS system and apply it to achieve diverse metabolic control in salicylic acid and 4-hydroxycoumarin biosynthesis in E. coli. |
| first_indexed | 2024-12-10T13:39:09Z |
| format | Article |
| id | doaj.art-bcff024dde454193957aee281b8012c9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T13:39:09Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bcff024dde454193957aee281b8012c92022-12-22T01:46:45ZengNature PortfolioNature Communications2041-17232022-04-0113111210.1038/s41467-022-29933-xRedesigning regulatory components of quorum-sensing system for diverse metabolic controlChang Ge0Zheng Yu1Huakang Sheng2Xiaolin Shen3Xinxiao Sun4Yifei Zhang5Yajun Yan6Jia Wang7Qipeng Yuan8State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologySchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of GeorgiaState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical TechnologyExisting quorum sensing (QS) circuits are less sophisticated for regulating multiple sets of genes or operons. Here, the authors redesign the luxR-luxI intergenic sequence of the lux-type QS system and apply it to achieve diverse metabolic control in salicylic acid and 4-hydroxycoumarin biosynthesis in E. coli.https://doi.org/10.1038/s41467-022-29933-x |
| spellingShingle | Chang Ge Zheng Yu Huakang Sheng Xiaolin Shen Xinxiao Sun Yifei Zhang Yajun Yan Jia Wang Qipeng Yuan Redesigning regulatory components of quorum-sensing system for diverse metabolic control Nature Communications |
| title | Redesigning regulatory components of quorum-sensing system for diverse metabolic control |
| title_full | Redesigning regulatory components of quorum-sensing system for diverse metabolic control |
| title_fullStr | Redesigning regulatory components of quorum-sensing system for diverse metabolic control |
| title_full_unstemmed | Redesigning regulatory components of quorum-sensing system for diverse metabolic control |
| title_short | Redesigning regulatory components of quorum-sensing system for diverse metabolic control |
| title_sort | redesigning regulatory components of quorum sensing system for diverse metabolic control |
| url | https://doi.org/10.1038/s41467-022-29933-x |
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