Post-Translational Modification Analysis of VDAC1 in ALS-SOD1 Model Cells Reveals Specific Asparagine and Glutamine Deamidation

Post-Translational Modification Analysis of VDAC1 in ALS-SOD1 Model Cells Reveals Specific Asparagine and Glutamine Deamidation

Mitochondria from affected tissues of amyotrophic lateral sclerosis (ALS) patients show morphological and biochemical abnormalities. Mitochondrial dysfunction causes oxidative damage and the accumulation of ROS, and represents one of the major triggers of selective death of motor neurons in ALS. We...

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Bibliographic Details
Main Authors: Maria Gaetana Giovanna Pittalà, Simona Reina, Salvatore Antonio Maria Cubisino, Annamaria Cucina, Beatrice Formicola, Vincenzo Cunsolo, Salvatore Foti, Rosaria Saletti, Angela Messina
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Antioxidants
Subjects:
deamidation
amyotrophic lateral sclerosis
voltage dependent anion channel
post-translational modifications
mitochondria
ROS
Online Access:https://www.mdpi.com/2076-3921/9/12/1218

Internet

https://www.mdpi.com/2076-3921/9/12/1218

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