Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.

Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the dev...

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Main Authors: Christina L Gardner, Jozef Hritz, Chengqun Sun, Dana L Vanlandingham, Timothy Y Song, Elodie Ghedin, Stephen Higgs, William B Klimstra, Kate D Ryman
格式: Article
語言:English
出版: Public Library of Science (PLoS) 2014-02-01
叢編:PLoS Neglected Tropical Diseases
在線閱讀:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002719&type=printable