Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.

Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.

Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the dev...

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Bibliographic Details
Main Authors: Christina L Gardner, Jozef Hritz, Chengqun Sun, Dana L Vanlandingham, Timothy Y Song, Elodie Ghedin, Stephen Higgs, William B Klimstra, Kate D Ryman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002719&type=printable

Internet

https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002719&type=printable

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