Synthesis and in vitro anticancer activity of 6-chloro-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives: molecular docking and interaction with bovine serum albumin

Synthesis and in vitro anticancer activity of 6-chloro-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives: molecular docking and interaction with bovine serum albumin

A novel series of 6-chloro-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives were synthesized. Structure of the newly synthesized compounds was established by their analytical and spectroscopic data. The title compounds were evaluated for their anticancer activity against human breast...

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Bibliographic Details
Main Authors: Supreet Gaonkar, Manjunath G. Sunagar, Narahari Deshapande, Ningaraddi S. Belavagi, Shrinivas D Joshi, Sheshagiri R Dixit, Imtiyaz Ahmed M. Khazi
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Journal of Taibah University for Science
Subjects:
Thiadiazolopyrimidinone
anticancer activity
bovine serum albumin
molecular docking
Online Access:http://dx.doi.org/10.1080/16583655.2018.1489036

Internet

http://dx.doi.org/10.1080/16583655.2018.1489036

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